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Base editing of haematopoietic stem cells rescues sickle cell disease in mice.
Newby GA, Yen JS, Woodard KJ, Mayuranathan T, Lazzarotto CR, Li Y, Sheppard-Tillman H, Porter SN, Yao Y, Mayberry K, Everette KA, Jang Y, Podracky CJ, Thaman E, Lechauve C, Sharma A, Henderson JM, Richter MF, Zhao KT, Miller SM, Wang T, Koblan LW, McCaffrey AP, Tisdale JF, Kalfa TA, Pruett-Miller SM, Tsai SQ, Weiss MJ, Liu DR. Newby GA, et al. Among authors: podracky cj. Nature. 2021 Jul;595(7866):295-302. doi: 10.1038/s41586-021-03609-w. Epub 2021 Jun 2. Nature. 2021. PMID: 34079130 Free PMC article.
The developing toolkit of continuous directed evolution.
Morrison MS, Podracky CJ, Liu DR. Morrison MS, et al. Among authors: podracky cj. Nat Chem Biol. 2020 Jun;16(6):610-619. doi: 10.1038/s41589-020-0532-y. Epub 2020 May 22. Nat Chem Biol. 2020. PMID: 32444838 Review.